The 2022 World Series was the 118th edition. It was a best-of-seven playoff between the Houston Astros and the Philadelphia Phillies. The Astros defeated the Phillies in six games to earn their second championship.

The Houston Astros entered the 2022 MLB postseason as the AL West champions and the top-seeded AL team, while the Phillies won a wild card, earning the sixth and final NL playoff berth. The Phillies took a 2–1 lead after three games, before the Astros won the final three games to win the series. 

The series was notable for having the first World Series no-hitter since Don Larsen's perfect game in the 1956 World Series, when Astros pitchers Cristian Javier, Bryan Abreu, Rafael Montero and Ryan Pressly achieved a combined no-hitter in Game 4. It was also the third postseason no-hitter in MLB history, after Roy Halladay's no-hitter (also pitched in Citizens Bank Park) in Game 1 of the 2010 National League Division Series.

Jeremy Peña won the World Series Most Valuable Player Award, becoming the first position player to win the award as a rookie.

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