The 2021 Major League Baseball All-Star Game was hosted by the Colorado Rockies and played at Coors Field on July 13, with the American League defeating the National League 5–2. It was the eighth consecutive All-Star Game victory for the AL.

The game was originally to be hosted in Atlanta at Truist Park. However, following the Georgia State Legislature's passage of the Election Integrity Act of 2021, the game was moved to Coors Field in Denver. The All-Star Game was the second to be played in Denver after the 1998 game.

Kevin Cash of the Tampa Bay Rays managed the AL and Dave Roberts of the defending World Series champion Los Angeles Dodgers managed the NL. For the first time in All-Star Game history, Los Angeles Angels player Shohei Ohtani served as the starting pitcher and lead-off batter. Toronto Blue Jays 1B Vladimir Guerrero Jr. was named the MVP.

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